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Table 1 Clinical characteristics and liver histology of study participants according to histological liver phenotype

From: Liver saturated fat content associates with hepatic DNA methylation in obese individuals

 

Normal liver

SS

NASH

p valuea

Total, n

24

12

15

–

Men/Women, n

8/16

5/7

6/9

n.s.

Age (years)

49.6 ± 8.3

47.3 ± 8.2

50.3 ± 9.2

n.s.

BMI (Kg/m2)

43.0 ± 6.3

44.4 ± 5.5

44.1 ± 6.6

n.s.

fS-Total cholesterol (mmol/L)

4.1 ± 0.7

4.0 ± 0.9

4.1 ± 0.9

n.s.

fS-LDL-c (mmol/L)

2.4 ± 0.7

2.1 ± 0.7

2.4 ± 0.7

n.s.

fS-HDL-c (mmol/L)

1.0 ± 0.2

0.9 ± 0.1

1.0 ± 0.2

n.s.

fS-TG (mmol/L)

1.2 (1.0–1.6)

1.8 (1.3–2.3)*

1.3 (1.0–1.9)

0.027

fP-Glucose (mmol/L)

5.8 ± 0.6

6.0 ± 1.2

6.7 ± 1.6

n.s.

fS-Insulin (mU/L)

12.9 (7.6–19.2)

14.9 (10.0–21.8)

15.8 (12.6–28)*

0.041

Type 2 diabetes (N/Y), n

18/6

6/6

6/9

n.s.

Total liver SFA content

61.7 ± 19.7

101.0 ± 34.2*

123.9 ± 65.5*

0.00002

  1. Data are shown as mean ± SD or median (IQR). fS—Fasting serum; fP—fasting plasma; LDL-c—low-density lipoprotein cholesterol; HDL-c—high-density lipoprotein cholesterol; TG—triglycerides; N/Y—no/yes; n—number of individuals; and SFA—saturated fatty acids. aOne-way ANOVA test (continuous variable) or χ2 test (categorical variable) over the three study groups; post hoc Bonferroni correction was used for multiple testing, *p value < 0.05 versus normal liver