Table 2 Diagnostic accuracy of various methylation biomarker panel
Biomarker | Area under the curve | P-value | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|
ADAMTS1 | 0.73 (0.61–0.83) | 0.001 | 60 | 86 |
BNC1 | 0.81 (0.70–0.90) |  < 0.001 | 66 | 97 |
CACNA1G | 0.63 (0.50–0.74) | 0.06 | 26 | 100 |
ADAMTS1/BNC1 | 0.80 (0.69–0.89) |  < 0.001 | 77 | 83 |
ADAMTS1/BNC1/CACNA1G | 0.81 (0.70–0.90) |  < 0.001 | 83 | 80 |
BNC1/CACNA1G | 0.84 (0.74–0.92) |  < 0.001 | 71 | 97 |
IPMN Lesion Size# | 0.66 (0.53–0.77) | 0.01 | 65 | 69 |
IPMN Lesion Size# and CA19-9 | 0.75(0.65–0.86) | 0.03 | 66 | 82 |
CA19-9 | 0.61 (0.50–0.72) | 0.06 | 34 | 88 |
IPMN Lesion Size#, CA19-9, & CACNA1G/BNC1 | 0.92 (0.86–0.98) |  < 0.001 | 94 | 88 |