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Fig. 3 | Clinical Epigenetics

Fig. 3

From: E2F1 combined with LINC01004 super-enhancer to promote hepatocellular carcinoma cell proliferation and metastasis

Fig. 3

Inhibition of SE activity can decrease LINC01004 expression. A Schematic diagram of JQ-1 inhibiting SE activity. B The expression of LINC01004 in SK-Hep-1 and HepG2 cells after JQ-1(10 μM) treatment for 48 h. **represents P < 0.01. C Schematic diagram of gRNAs design and CRISPR-dCas9. D GFP fluorescence results of HepG2 cells after gRNA-dCas9 vectors transfection for 48 h. E Western blot results of HepG2 cells after gRNA-dCas9 vectors transfection for 48 h. F The expression of LINC01004 in HepG2 cells after gRNA-dCas9 vectors transfection for 48 h. **represents P < 0.01

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