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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells

Fig. 4

ZSCAN18 regulates TP53INP2 transcriptionally and binds to the TP53INP2 promoter region. A The volcano plots of DEGs were generated from mRNA sequencing analysis of ZSCAN18-overexpressed and control NCI-N87 cells. B ZSCAN18 is correlated with TP53INP2 in GC (http://gepia.cancer-pku.cn). C TP53INP2 increased after ZSCAN18 overexpression in AGS and NCI-N87 cells measured by qRT-PCR (left) and western blot (right). D ZSCAN18 was enriched in the promoter region of TP53INP2 according to bioinformation analysis (http://genome.ucsc.edu/cgi-bin). E Chip assay confirmed that ZSCAN18 could bind to the TP53INP2 promoter region in both AGS and NCI-N87 cells. Each experiment was performed in triplicate and repeated at least three times. Data were represented as mean ± SD. ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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