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Table 3 Methylation differences in the seven target genes between inflammatory cell types

From: Hypomethylation in MTNR1B: a novel epigenetic marker for atherosclerosis profiling using stenosis radiophenotype and blood inflammatory cells

 

No-stenosis (n = 28)

Stenosis (n = 142)

p value

EFNA2

Monocyte

8 ± 3.9

9.2 ± 3.7

0.118

T cell

11.8 ± 4.1

11.9 ± 3.3

0.884

B cell

7.8 ± 3.9

9.2 ± 4.1

0.115

Buffy coat

10.3 ± 2.6

10.2 ± 4

0.901

ENOSF1

Monocyte

45.3 ± 17.6

47.3 ± 16.8

0.562

T cell

47.3 ± 17.7

51.1 ± 16.3

0.268

B cell

48.7 ± 20.5

54.6 ± 16.3

0.096

Buffy coat

47.2 ± 16.8

48.9 ± 16.2

0.618

GLS2

Monocyte

30.1 ± 9.2

31.5 ± 7.7

0.412

T cell

43.1 ± 7.7

43.7 ± 5.7

0.622

B cell

40.6 ± 10.4

42.5 ± 10.1

0.375

Buffy coat

36.3 ± 7.9

36.1 ± 7.4

0.944

KNDC1

Monocyte

20.2 ± 5.7

21.3 ± 6.1

0.366

T cell

25.1 ± 4.6

26 ± 4.7

0.323

B cell

22.4 ± 5.2

23.1 ± 4.9

0.485

Buffy coat

21.3 ± 5.1

22.3 ± 5.4

0.383

MTNR1B

Monocyte

17.4 ± 10.8

16.2 ± 6.2

0.412

T cell

37.1 ± 9.6

40.6 ± 6.8

0.02

B cell

42.1 ± 15.3

37.7 ± 8.3

0.04

Buffy coat

27 ± 10.3

23.8 ± 7.5

0.052

PAX8-AS1

Monocyte

65.3 ± 21.4

62.4 ± 21.8

0.546

T cell

60 ± 15.2

58.4 ± 16.3

0.635

B cell

63.5 ± 18.5

61.9 ± 19.2

0.701

Buffy coat

63.7 ± 17.3

60.1 ± 20.6

0.393

TLDC1

Monocyte

15.6 ± 5.7

18.7 ± 6.8

0.025

T cell

20.3 ± 7.4

20.6 ± 5.4

0.77

B cell

18.8 ± 7.9

20.1 ± 7.8

0.43

Buffy coat

15.7 ± 5.6

18.2 ± 6.2

0.049

  1. Data represent mean ± SD (%)