Skip to main content

Table 2 Comparison of prediction performance after adding seven gene-specific promoter methylations to traditional cardiovascular risk factors

From: Hypomethylation in MTNR1B: a novel epigenetic marker for atherosclerosis profiling using stenosis radiophenotype and blood inflammatory cells

Risk factors + blood tests

Risk factors + blood tests + gene-specific methylation

Risk factors + blood tests + gene-specific methylation

Variables

Coefficient (95% CI)

p value

Variables

Coefficient (95% CI)

p value

Important variables

Score

Age

0.057 (0.018–0.098)

0.017

Age

0.096 (0.05–0.145)

0.001

Lipoprotein (a)

100

Hypertension: Yes

1.182 (0.527–1.868)

0.004

Hypertension: yes

0.99 (0.291–1.716)

0.022

Age

93.47

Creatinine

2.864 (0.492–5.409)

0.055

Creatinine

2.727 (0.184–5.462)

0.088

Hypertension: Yes

87.81

Lipoprotein (a)

0.044 (0.023–0.071)

0.002

Lipoprotein (a)

0.048 (0.025–0.076)

0.002

MTNR1B

76.07

   

Homocysteine

0.102 (0.016–0.218)

0.086

PAX8.AS1

66.5

   

MTNR1B

 − 0.099 (− 0.148 to − 0.052)

0.001

TLDC1

53.59

      

Homocysteine

50.8

Performance of the prediction model

Accuracy

0.891

0.893

0.887

Sensitivity

0.28

0.36

0.533

Specificity

0.982

0.973

0.94

AUC

0.845

0.88

0.877

  1. AUC Area under the curve, CI Confidence interval