Risk factors + blood tests | Risk factors + blood tests + gene-specific methylation | Risk factors + blood tests + gene-specific methylation | |||||
---|---|---|---|---|---|---|---|
Variables | Coefficient (95% CI) | p value | Variables | Coefficient (95% CI) | p value | Important variables | Score |
Age | 0.057 (0.018–0.098) | 0.017 | Age | 0.096 (0.05–0.145) | 0.001 | Lipoprotein (a) | 100 |
Hypertension: Yes | 1.182 (0.527–1.868) | 0.004 | Hypertension: yes | 0.99 (0.291–1.716) | 0.022 | Age | 93.47 |
Creatinine | 2.864 (0.492–5.409) | 0.055 | Creatinine | 2.727 (0.184–5.462) | 0.088 | Hypertension: Yes | 87.81 |
Lipoprotein (a) | 0.044 (0.023–0.071) | 0.002 | Lipoprotein (a) | 0.048 (0.025–0.076) | 0.002 | MTNR1B | 76.07 |
 |  |  | Homocysteine | 0.102 (0.016–0.218) | 0.086 | PAX8.AS1 | 66.5 |
 |  |  | MTNR1B |  − 0.099 (− 0.148 to − 0.052) | 0.001 | TLDC1 | 53.59 |
 |  |  |  |  |  | Homocysteine | 50.8 |
Performance of the prediction model | |||||||
Accuracy | 0.891 | 0.893 | 0.887 | ||||
Sensitivity | 0.28 | 0.36 | 0.533 | ||||
Specificity | 0.982 | 0.973 | 0.94 | ||||
AUC | 0.845 | 0.88 | 0.877 |