Table 1 Comparison of risk factors and laboratory tests between patients with and without stenosis
|  | No-stenosis (n = 50) | Stenosis (n = 334) | p value |
|---|---|---|---|
Age (years, ± SD) | 63.8 ± 8.8 | 69.4 ± 8.9 |  < 0.001 |
Sex (men/women, %) | 26:24 (52%:48%) | 218:116 (65%:35%) | 0.069 |
Body mass index | 25 ± 3 | 24.9 ± 3.2 | 0.819 |
Stroke severity | |||
NIHSS-admission | 0.5 ± 1.4 | 0.9 ± 1.9 | 0.18 |
NIHSS-discharge | 0.2 ± 0.6 | 0.4 ± 1 | 0.155 |
Cranial vessel stenosis number | |||
Extracranial vessels | 0 ± 0 | 2.1 ± 1.2 |  |
Intracranial vessels | 0 ± 0 | 2.4 ± 2.5 |  |
Extra- + intracranial vessels | 0 ± 0 | 4.5 ± 2.9 |  |
Clinical risk factors | |||
Hypertension | 17 (34%) | 212 (64%) |  < 0.001 |
Diabetes | 7 (14%) | 108 (32%) | 0.008 |
Smoking | 12 (24%) | 107 (32%) | 0.252 |
Blood tests | |||
Hemoglobin (g/dL) | 13.7 ± 1.4 | 13.7 ± 1.6 | 0.861 |
White blood cells (/μL) | 6456.6 ± 1512.9 | 7027.3 ± 2105 | 0.066 |
Platelets (103/μL) | 234.5 ± 46.5 | 222.3 ± 62.2 | 0.184 |
High-sensitive C-reactive protein (mg/L) | 1.6 ± 2.2 | 3.8 ± 9.9 | 0.118 |
Homocysteine (μmol/L) | 8.7 ± 2.4 | 10 ± 4.7 | 0.049 |
Creatinine (mg/dL) | 0.7 ± 0.2 | 0.8 ± 0.2 | 0.003 |
Total cholesterol (mg/dL) | 181.9 ± 34.2 | 169.9 ± 42.2 | 0.056 |
Triglyceride (mg/dL) | 130.9 ± 73.9 | 126.8 ± 80.4 | 0.738 |
High-density lipoprotein cholesterol (mg/dL) | 51.7 ± 13.7 | 45.9 ± 11.3 | 0.001 |
Low-density lipoprotein cholesterol (mg/dL) | 108.8 ± 27.2 | 102.6 ± 35.7 | 0.234 |
Apolipoprotein A (mg/dL) | 134.3 ± 27.1 | 122.8 ± 25.1 | 0.003 |
Apolipoprotein B (mg/dL) | 89.4 ± 20.3 | 88.4 ± 25 | 0.778 |
Lipoprotein (a) (mg/dL) | 15.2 ± 11.5 | 25.2 ± 21.7 | 0.002 |
Hemoglobin A1c (%) | 5.9 ± 0.8 | 6.3 ± 1.4 | 0.04 |
Fasting blood glucose (mg/dL) | 113.3 ± 29.8 | 129.5 ± 56.2 | 0.047 |
Gene-specific promoter methylations | |||
EFNA2 | 10 ± 2.4 | 10.4 ± 4.1 | 0.456 |
ENOSF1 | 48.1 ± 17.7 | 49.6 ± 17 | 0.552 |
GLS2 | 35.6 ± 6.7 | 35.3 ± 6.9 | 0.749 |
KNDC1 | 21.4 ± 4.4 | 22.3 ± 5.2 | 0.276 |
MTNR1B | 25.4 ± 8.7 | 22.7 ± 6.7 | 0.009 |
PAX8-AS1 | 63.6 ± 16.9 | 58.9 ± 19.7 | 0.105 |
TLDC1 | 18.3 ± 6.1 | 18.3 ± 5.8 | 0.969 |