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Table 1 Top 20 prominently enriched KEGG pathways of the DMP between sMPLC and SPLC

From: Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer

Pathway ID

Pathway description

Diff gene/all genes in this pathway

Rich factor

p value

Q value

Gene list

hsa04725

Cholinergic synapse

18/112

3.66004

3.08E-06

0.000831

CREB3L3, KCNQ5, GNG12, PIK3R3, ADCY5, BCL2, AKT3, CHRNA3, PLCB2, CAMK2B, ADCY7, KCNQ2, ADCY9, PRKCB, CHRM1, GNG7, GNG4, CACNA1A

hsa04973

Carbohydrate digestion and absorption

6/44

3.105489

0.007932

0.082373

LCT, PIK3R3, AKT3, PLCB2, PRKCB, GNAT3

hsa04713

Circadian entrainment

13/96

3.083923

0.000309

0.020872

CACNA1I, GNG12, PRKG1, ADCY5, GRIN2B, PLCB2, CAMK2B, ADCY7, ADCY9, RYR3, PRKCB, GNG7, GNG4

hsa04724

Glutamatergic synapse

15/114

2.996524

0.000172

0.015514

SLC1A7, DLGAP1, GRM4, GNG12, ADCY5 GRIN2B, PLCB2, ADCY7, ADCY9, PPP3R1, PRKCB, GRM7, GNG7, GNG4, CACNA1A

hsa04923

Regulation of lipolysis in adipocytes

7/54

2.952131

0.006607

0.081085

PRKG1, PIK3R3, ADCY5, AKT3, ADCY7, ADCY9, PTGER3

hsa04062

Chemokine signaling pathway

23/184

2.846698

1.33E-05

0.001798

CXCL2, NFKBIA, CXCR1, GNG12, TIAM1, PIK3R3, ADCY5, AKT3, PLCB2, PRKCZ, ADCY7, ADCY9, ROCK2, CCR7, STAT3, CCR8, PRKCB, PARD3, CCL1, GNG7, PREX1, GNG4, ELMO1

hsa04931

Insulin resistance

13/107

2.766884

0.000896

0.03457

NFKBIA, PRKCE, CREB3L3, PIK3R3, PRKAG2, AKT3, PCK1, PRKCZ, STAT3, PRKCB, GFPT2, RPS6KA2, PPP1R3E

hsa05143

African trypanosomiasis

4/34

2.679245

0.037482

0.206534

LAMA4, PLCB2, PRKCB, TLR9

hsa04911

Insulin secretion

10/85

2.679245

0.003709

0.066757

ABCC8, CREB3L3, ADCY5, PLCB2, KCNMB2, CAMK2B, ADCY7, ADCY9, PRKCB, KCNMB3

hsa04925

Aldosterone synthesis and secretion

11/95

2.636941

0.002906

0.07134

CACNA1I, PRKCE, CREB3L3, ADCY5, KCNK9, PLCB2, CAMK2B, ADCY7, ADCY9, PRKCB, SCARB1

hsa04728

Dopaminergic synapse

15/131

2.607662

0.000783

0.035218

CREB3L3, GNG12, LRTOMT, ADCY5, GRIN2B, AKT3, PLCB2, CAMK2B, PPP2R2B, PRKCB, GNG7, PPP2R5C, KIF5C, GNG4, CACNA1A

hsa04727

GABAergic synapse

10/88

2.587907

0.004817

0.081294

SLC6A11, GNG12 ADCY5, GABRG3, ADCY7, ADCY9, PRKCB, GNG7, GNG4, CACNA1A

hsa04213

Longevity regulating pathway—multiple species

7/62

2.571211

0.014668

0.11315

PIK3R3, ADCY5, PRKAG2, AKT3, ADCY7, ADCY9, HSPA8

hsa04071

Sphingolipid signaling pathway

13/118

2.508954

0.002244

0.060583

PRKCE, PIK3R3, BCL2, AKT3, PLCB2, PRKCZ, PPP2R2B, SGMS2, ROCK2, PRKCB, DEGS2, PPP2R5C, SGMS1

hsa05032

Morphine addiction

10/91

2.502592

0.006179

0.079448

GNG12, ADCY5, GABRG3, ADCY7, ADCY9, PRKCB, PDE8A, GNG7, GNG4, CACNA1A

hsa04512

ECM–receptor interaction

9/82

2.49954

0.008714

0.084029

LAMB3, LAMA4, SV2B, ITGB5, ITGB4, ITGA11, CD47, LAMA3, LAMB1

hsa04930

Type II diabetes mellitus

5/46

2.47539

0.035767

0.201192

ABCC8, PRKCE, PIK3R3, PRKCZ, CACNA1A

hsa04660

T cell receptor signaling pathway

11/103

2.43213

0.005554

0.078927

NFKBIA, PAK6, GRAP2, CBLB, PIK3R3, AKT3, CD247, PPP3R1, ZAP70, NCK2, MAP3K14

hsa05146

Amoebiasis

10/94

2.422722

0.007834

0.084603

LAMB3, LAMA4, PIK3R3, PLCB2, CD1D, ITGAM, PRKCB, IL1R2, LAMA3, LAMB1

hsa05223

Non-small cell lung cancer

7/66

2.41538

0.020755

0.136676

PIK3R3, AKT3, RARB, STAT3, PRKCB, EML4, ALK

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Clinical Epigenetics

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