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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer

Fig. 5

A, B and C In SPLC patients, 30 immune-related DEGs were identified with 15 genes down-regulated and 15 genes up-regulated. In sMPLC patients, 58 immune-related DEGs were identified with 50 genes down-regulated and 8 genes up-regulated. Fourteen DEGs were shared in both groups. D and E Visualizing biomolecular interaction network in SPLC and sMPLC. F CIBERSORT analyses revealed immune cell infiltrating differences between SPLC and sMPLC patients. In both groups, tumor tissues showed more significant infiltration of naïve B cells, TfH cells, Tregs, activated NK cells, resting dendritic cells, and macrophages. Moreover, in the sMPLC group, memory B cells, plasma cells, and activated mast cells were significantly more infiltrated in tumor tissues than normal lung tissues. Interestingly, a certain group of immune cells (B cells, dendritic cells, Tregs, and activated memory CD4+ T cells) showed significant infiltrating differences even in normal lung tissues between SPLC and sMPLC patients. *, p < 0.05; **, p < 0.01; ***, p < 0.001. sMPLC, tumors from sMPLC group; sMPLC-N, normal lung tissues from sMPLC group; SPLC, tumors from SPLC group; SPLC-N, normal lung tissues from SPLC group

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Clinical Epigenetics

ISSN: 1868-7083

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