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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer

Fig. 3

Genome-wide DNA methylation patterns in sMPLC and SPLC. A The heatmap and cluster analysis showed that, in sMPLC, unlike the high heterogeneity in the genome, the DNA methylation patterns were very similar among the multiple lesions from the same patient. B Based on the genome-wide DNA methylation patterns, the sMPLC and SPLC tumor samples could be directly clustered into two groups. C The DNA methylation level of SPLC tumors around the transcription starting site (TSS) was significantly higher than that in the sMPLC tumors. D and E DMP identified in sMPLC and SPLC tumors, compared to their normal lung tissues. The genes corresponding to the top 20 differences in DMP are listed at the two tips of the volcanic map. F DMP identified between sMPLC and SPLC tumors. The genes corresponding to the top 20 differences in DMP are listed at the two tips of the volcanic map. MC, multiple primary lung cancers; SC, single primary lung cancer

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Clinical Epigenetics

ISSN: 1868-7083

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