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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts

Fig. 5

gDMR methylation in mouse blastocysts from natural ovulation and superovulation adult conditions. a Bar chart showing the proportion of reads that present full methylation, mixed methylation or full unmethylation for combined gDMRs in each individual blastocyst. b Strip chart and boxplot illustrating methylation at 17 gDMRs common to all blastocysts from the NO, SOa and SOp conditions. Each dot represents the combined methylation level of an individual gDMR in the blastocysts of the respective group. Boxplots show median value and 25–75th percentiles and whiskers show the lowest and highest observation. c Heatmap showing methylation levels at the 19 gDMRs common to all blastocysts within the NO and SOa conditions. Differentially methylated gDMRs are highlighted (determined by logistic regression analysis in SeqMonk; p < 0.05 corrected for multiple comparisons using Benjamini–Hochberg, methylation difference ≥ 10%). d Table indicating methylation and p values of the differentially methylated gDMRs. gDMR, maternally methylated germline differentially methylated region; NO, natural ovulation; SOa, superovulation adult; SOp, superovulation prepubertal

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