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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts

Fig. 2

DNA methylation differences in mouse blastocysts from natural ovulation and superovulation adult conditions. a Scatterplot showing correlation between methylation levels of individual 100-CpG tiles common to all datasets (n = 206,059) in mouse blastocysts of the indicated two conditions, using data merged for the 4 samples per group. Differentially methylated tiles were determined by logistic regression analysis in SeqMonk (p < 0.05 corrected for multiple comparisons using Benjamini–Hochberg, methylation difference ≥ 10%). Red and blue indicate differentially methylated tiles that are hypermethylated or hypomethylated, respectively, in the NO group. b Heatmap showing the 100-CpG differentially methylated tiles identified between NO and SOa groups (n = 401). c Beanplots indicating methylation levels in blastocysts of the CGIs identified as methylated in MII oocytes (n = 1226); within each beanplot, boxplot shows median value and 25–75th percentiles and whiskers show the lowest and highest observation. d Heatmap showing the 13 differentially methylated CGIs identified between NO and SOa groups and the overlapping genes. CGI promoters are indicated in bold. NO, natural ovulation; SOa, superovulation adult; CGI, CpG island

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