CpG sites | Controls | Stroke cases | Crude OR (95% CI) | P value | OR (95% CI)☆ | P value☆ | OR (95% CI)* | P value* |
---|---|---|---|---|---|---|---|---|
Median (IQR) | Median (IQR) | Per + 10% methylation | Per + 10% methylation | Per + 10% methylation | ||||
HTRA1_A_CpG_1 | 0.09 (0.05–0.12) | 0.10 (0.07–0.13) | 1.27 (0.92–1.75) | 0.146 | 1.27 (0.92–1.76) | 0.140 | 1.22 (0.85–1.77) | 0.284 |
HTRA1_A_CpG_2 | 0.65 (0.56–0.73) | 0.64 (0.58–0.74) | 1.01 (0.92–1.12) | 0.803 | 1.01 (0.92–1.12) | 0.821 | 0.99 (0.88–1.11) | 0.860 |
HTRA1_A_CpG_3 | 0.29 (0.22–0.35) | 0.29 (0.24–0.35) | 0.96 (0.78–1.17) | 0.662 | 0.95 (0.78–1.16) | 0.636 | 0.92 (0.73–1.15) | 0.466 |
HTRA1_A_CpG_4 | 0.12 (0.09–0.15) | 0.13 (0.11–0.15) | 1.48 (0.96–2.30) | 0.078 | 1.47 (0.95–2.28) | 0.087 | 1.29 (0.79–2.11) | 0.310 |
HTRA1_A_CpG_5 | 0.37 (0.31–0.45) | 0.38 (0.30–0.45) | 0.99 (0.86–1.14) | 0.891 | 0.99 (0.86–1.14) | 0.903 | 0.99 (0.85–1.16) | 0.913 |
HTRA1_A_CpG_6 | 0.12 (0.10–0.15) | 0.10 (0.06–0.13) | 0.50 (0.32–0.78) | 0.002 | 0.51 (0.33–0.79) | 0.003 | 0.54 (0.34–0.86) | 0.009 |
HTRA1_A_CpG_7 | 0.36 (0.28–0.45) | 0.37 (0.30–0.45) | 1.08 (0.92–1.27) | 0.343 | 1.07 (0.92–1.26) | 0.378 | 1.09 (0.91–1.30) | 0.369 |
HTRA1_B_CpG_1 | 0.16 (0.09–0.41) | 0.18 (0.11–0.44) | 1.04 (0.95–1.13) | 0.384 | 1.04 (0.96–1.14) | 0.333 | 1.05 (0.95–1.16) | 0.308 |
HTRA1_B_CpG_2 | 0.09 (0.05–0.12) | 0.10 (0.07–0.14) | 1.45 (1.02–2.06) | 0.039 | 1.45 (1.02–2.06) | 0.040 | 1.25 (0.86–1.82) | 0.243 |
HTRA1_B_CpG_3.4 | 0.28 (0.24–0.33) | 0.29 (0.25–0.34) | 1.18 (0.90–1.55) | 0.236 | 1.19 (0.90–1.57) | 0.221 | 1.11 (0.81–1.52) | 0.513 |
HTRA1_B_CpG_5 | 0.26 (0.20–0.34) | 0.28 (0.22–0.33) | 1.09 (0.90–1.33) | 0.378 | 1.10 (0.90–1.34) | 0.367 | 1.06 (0.85–1.32) | 0.612 |
HTRA1_B_CpG_7 | 0.47 (0.36–0.54) | 0.47 (0.37–0.54) | 1.06 (0.92–1.22) | 0.456 | 1.06 (0.92–1.22) | 0.448 | 1.01 (0.85–1.19) | 0.957 |
HTRA1_B_CpG_8.9 | 0.28 (0.24–0.33) | 0.29 (0.25–0.34) | 1.18 (0.90–1.55) | 0.236 | 1.19 (0.90–1.57) | 0.221 | 1.11 (0.81–1.52) | 0.513 |
HTRA1_B_CpG_10 | 0.61 (0.53–0.71) | 0.63 (0.55–0.70) | 1.06 (0.92–1.23) | 0.445 | 1.06 (0.92–1.23) | 0.423 | 1.03 (0.87–1.22) | 0.722 |
HTRA1_B_CpG_11.12 | 0.72 (0.65–0.80) | 0.73 (0.66–0.80) | 1.09 (0.92–1.30) | 0.315 | 1.10 (0.92–1.31) | 0.300 | 1.07 (0.88–1.31) | 0.504 |
HTRA1_B_CpG_13.14.15 | 0.49 (0.41–0.57) | 0.51 (0.45–0.57) | 1.15 (0.97–1.36) | 0.115 | 1.15 (0.97–1.36) | 0.109 | 1.12 (0.92–1.36) | 0.261 |
HTRA1_B_CpG_16 | 0.53 (0.45–0.63) | 0.53 (0.45–0.68) | 1.03 (0.91–1.17) | 0.636 | 1.03 (0.91–1.17) | 0.658 | 0.99 (0.86–1.15) | 0.911 |