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Fig. 7 | Clinical Epigenetics

Fig. 7

From: Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer

Fig. 7

Altered sperm DNA methylation in cancer patients demonstrates mainly acute changes, with some patients showing common alterations and persistent changes over time. A Venn diagrams of altered sperm DNA methylation within patients across different collection time points. B Acute hypo- and hypermethylation observed at 6 months following chemotherapy treatments. C Intersection of DMCs from two HD patients (right) with gene ontology (GO) analysis performed using common DMRs (left). D GO analysis of DMCs found to persist throughout all time points from patient HD2. Top 20 most significant GO biological processes, by weighted Fisher p values, are plotted with the number in bars representing the number of significant genes annotated to DMRs/DMCs. Enrichment is calculated as a ratio of genes affected and the number of genes found within each GO biological process (see Additional file 1 for all significant GO terms). Dashed vertical line, p = 0.05

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