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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer

Fig. 3

Schematic of the largest differentially methylated region (DMR) discovered following three-group ANOVA and post hoc Tukey’s test for HD. A UCSC genome browser view of the region encompassing the long non-coding RNA, LOC100130872, and the SPON2 (Spondin 2) gene, with tracks showing location of 450 K probes (450 K CpGs) and all CpGs (CpG sites) within the region. Graphs of the average beta-value from each patient group are depicted, plotting the sites according to their B relative position within the genome and C separated to indicate SEM and significant CpG sites as discovered following post hoc testing. Highlighted areas in B and C indicate the DMR discovered following three-group ANOVA, while * indicates significant differences in post hoc Tukey’s testing. Mean ± SEM, *p < 0.05

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