Fig. 2
From: Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Heatmap representation of DNA methylation of promoter (A), gene (C), and CGI-DMRs (E) in 12 MTLE patients compared with 11 controls. The DNA methylation value of each DMR corresponds to the mean beta value across all single-nucleotide positions encompassed by the DMR. Each individual is annotated with respect to age and sex. GO enrichment analysis of hypermethylated and hypomethylated DMRs across the promoter (B), gene (D), and CGI-DMR (F) types, showing the most biologically relevant terms. GO categories include biological process (BP), molecular function (MF), cellular component (CC) and human phenotype (HP). Enrichment is represented by p value and fold enrichment. For each GO term, the corresponding DMR hits were identified in a heatmap. NES and beta difference values (MTLE-CTR) for each gene were included to represent the degree of differential methylation. G HOMER binding motif enrichment of hypomethylated and hypermethylated DMRs. Colour depicts the transcription factor family; bubble size indicates the level of significance (p)