Fig. 5From: BDNF exon IV promoter methylation and antidepressant action: a complex interplayEffect of DNMT overexpression on BDNF exon IV promoter activity. a DNMT 3a overexpression significantly increases BDNF exon IV promoter activity (P < 0.0001). DNMT3b and DNMT1 do not have any significant effect. b Venlafaxine further increases the DNMT3a-mediated increase in promoter activity (P < 0.01). Fluoxetine has no significant effectBack to article page