Fig. 2
From: BDNF exon IV promoter methylation and antidepressant action: a complex interplay
a Effect of antidepressants on BDNF exon IV promoter activity. The antidepressants at the given concentration decrease the promoter activity: Venlafaxine (50 µM, P < 0.001), Fluoxetine (10 µM, P < 0.05), Mirtazapine (50 µM, P < 0.05) and Lithium carbonate (3 mM, P < 0.01). Overall, methylation reduces the promoter activity (ANOVA, main effect of methylation: P = 0.0008). There is no significant reduction in promoter activity on AD treatment in methylated fragment