Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation

Clinical Epigenetics

Table 3 Association of CpGs that have statistically significant change in DNA methylation after cardiac surgery with postoperative atrial fibrillation (POAF)

CpG	Mean methylation change in patients with POAF	Mean methylation change in patients without POAF	P value
chr5:173153463	0.063	0.043	0.294
chr6:64569557	0.035	0.012	0.042
chr12:61472036	−0.021	−0.006	0.160
chr21:20040011	−0.007	−0.008	0.982
chr22:19192301	0.071	0.020	0.029

Of the 84 patients in this cohort without a history of atrial fibrillation, 33 experienced new-onset postoperative atrial fibrillation (POAF) after cardiac surgery for an incidence of 39%. For CpGs that have a statistically significant change in DNA methylation after cardiac surgery, the change in percent methylation in patients who experienced POAF was compared to the change in percent methylation in patients who did not experience POAF using the Wilcoxon rank-sum test. Notably, a greater magnitude change in DNA methylation is associated with POAF occurrence at chr6:64569557 and chr22:19192301, the two CpGs with statistically significant changes in DNA methylation associated with POAF

ISSN: 1868-7083