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Table 2 CpGs with a statistically significant change in DNA methylation after cardiac surgery

From: Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation

CpG

Nearest gene

Location

Pre-Op mean % methylation

Mean % methylation change

P value

FDR

chr5:173153463

BNIP1

Inside intron

60.84

4.79

1.36E-06

0.022

chr6:64569557

EYS

Inside intron

47.85

1.92

2.68E-06

0.022

chr12:61472036

LOC105369793

Downstream

72.25

−1.24

2.59E-06

0.022

chr21:20040011

LINC01683

Upstream

70.39

−0.61

2.35E-06

0.022

chr22:19192301

CLTCL1

Inside intron

62.02

4.67

2.04E-06

0.022

  1. Five CpGs had a statistically significant change in DNA methylation after cardiac surgery (FDR < 0.05) in a paired analysis by individual that models methylation count data for all CpGs and controls for preoperative and postoperative cell-type heterogeneity