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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation

Fig. 3

Significant DNA methylation changes after cardiac surgery are not a measure of the extent of Inflammation. Of the 96 patients in our study, 20 had preoperative and postoperative IL-6 levels available. Panel (A) shows that IL-6 levels increase significantly from preoperative to postoperative sampling, demonstrating increased inflammation after cardiac surgery. Panels (B) through (F) plot change in DNA methylation at 24 h by change in IL-6 level at 24 h for each CpG that has a statistically significant change in DNA methylation after cardiac surgery. Each point on these scatter plots represents one patient sample. A regression line and its accompanying R demonstrate a lack of linear relationship between change in DNA methylation after cardiac surgery and IL-6 levels

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