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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Epigenetic dysregulation-mediated COL12A1 upregulation predicts worse outcome in intrahepatic cholangiocarcinoma patients

Fig. 3

COL12A1 upregulation predicts worse clinical outcomes in iCCA patients. A Boxplots to show COL12A1 mRNA levels in adjacent nontumor and tumor specimens stratified by TNM stage (Stage I to Stage IV) from TCGA or OEP001105 iCCA cohort. ns, p ≥ 0.05. *p < 0.05, ***p < 0.001, based on Bonferroni post-tests. B Boxplots to show COL12A1 protein levels in adjacent nontumor and tumor specimens stratified by TNM stage (Stage I to Stage IV) from LVC1202 or OEP001105 cohort. ns, p ≥ 0.05. *p < 0.05, ****p < 0.001, based on Bonferroni post-tests. C Overall survival curves stratified by COL12A1 mRNA expression levels in iCCA patients included in TCGA, E-MTAB-6389 or OEP001105 cohort, respectively. p is based on log-rank test. D Overall survival curves stratified by COL12A1 protein expression levels in two independent iCCA cohorts (OEP001105 and LVC1202). p is based on log-rank test. E Boxplot to show the median overall survival time of iCCA patients with COL12A1-high/low expression from TCGA, E-MTAB-6389, OEP001105 and LVC1202 cohorts. *p < 0.05, based on two-tailed unpaired Student's t test. F Recurrence probability curves stratified by the expression level of COL12A1 in iCCA patients. p is based on log-rank test. G Forest plot showing multivariate survival analysis result from the Cox’s regression model. TCGA-iCCA cohort is from The Cancer Genome Atlas (TCGA); E-MTAB-6389 iCCA cohort is from ArrayExpress; OEP001105 iCCA cohort is from National Omics Data Encyclopedia (NODE). iCCA intrahepatic cholangiocarcinoma, TCGA The Cancer Genome Atlas

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