Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors

Table 3 Top 25 hypomethylated sites in placental DNAs in LGA vs. OGA newborns

CpG	Gene	Gene Group	Adjusted P	Avg_ LGA	Avg_ OGA	Delta Beta
cg01799062	FAM155A	Body	0.042	0.49	0.65	− 0.16
cg22120852			0.039	0.58	0.73	− 0.15
cg10068793	C21orf34	TSS1500	0.036	0.53	0.68	− 0.15
cg02824489	WNT5B	Body	0.036	0.65	0.79	− 0.14
cg20509944	DTNA	TSS200;5'UTR	0.034	0.54	0.68	− 0.14
cg14348757	OPRM1	1stExon; Body	0.034	0.31	0.45	− 0.14
cg03917817			0.037	0.56	0.69	− 0.13
cg15489003			0.029	0.26	0.39	− 0.13
cg17718664	SORCS3	TSS1500;Body	0.016	0.48	0.61	− 0.13
cg22492024			0.033	0.45	0.57	− 0.12
cg11912591	KIF26B	Body	0.044	0.25	0.37	− 0.12
cg10500641			0.025	0.71	0.83	− 0.13
cg09801894			0.040	0.66	0.78	− 0.12
cg06631347	SLCO3A1	Body	0.045	0.71	0.83	− 0.12
cg08886301	KIF26B	Body	0.025	0.35	0.46	− 0.11
cg25379995	LOC284930	Body	0.029	0.52	0.63	− 0.11
cg02255236	SLIT3	Body	0.040	0.81	0.92	− 0.11
cg10443049	NXPH1	Body	0.040	0.18	0.29	− 0.11
cg27538194			0.049	0.43	0.54	− 0.11
cg10104921			0.045	0.50	0.61	− 0.11
cg17512353	HLA-L	Body	0.034	0.52	0.62	− 0.10
cg03370491			0.013	0.54	0.64	− 0.10
cg07409443			0.035	0.44	0.54	− 0.10
cg13306032			0.039	0.21	0.31	− 0.10
cg10358197			0.048	0.46	0.56	− 0.10

LGA, large-for-gestational-age (birth weight > 90^th percentile); OGA = optimal-for-gestational-age (birth weight 25^th-75^th percentiles)
The gene name in bold, the CpG site was selected in the pyrosequencing validation study

ISSN: 1868-7083