Skip to main content
Fig. 2 | Clinical Epigenetics

Fig. 2

From: Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance

Fig. 2

Global characterization of methylation status of the sperm populations. Normalized CpG methylation levels were compared in the pooled sperm fractions of healthy semen donors and infertile patients with shortened AGD (A), in the sperm fractions of both groups of participants based on uptake or non-uptake of CMA3 (B) and based on uptake or non-uptake of YOPRO (C). Normalized CpG methylation levels significantly lower in CMA3− negative sperm fraction (CMA3−) of infertile patients as compared to that of healthy donors (p = 0.039). No differences in normalized CpG methylation levels were detected in the sperm fractions sorted based on YOPRO− uptake. Differences in the normalized CpG levels with examined both with ANOVA and with Kruskal–Wallis

Back to article page