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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data

Fig. 2

Differential H3K4me3 occupancy in the low and high BPA groups. Functional annotation analysis of differential regions. A Gene ontology annotation with “molecular function” terms was performed by GREAT. Terms were sorted by p value. B H3K4me3 regions in TERF2IP and ZBTB48. Reads were mapped and plotted on a graph by IGV; blue represents the low BPA group, and red represents the high BPA group. C Comparison of genes located in differential peaks and protein‒protein interaction (PPI) analysis; the second column shows the number of genes identified for each transcription factor compared to the total number of known interacting proteins. D Motif found by MEME. Parts of this motif are similar to the binding sites of E the methyl binding protein MBD2 and F the methyl binding protein MECP2. The E-value shows the statistical significance of the motif. G ESR1 binding sites. The E-value shows the statistical significance of the motif presence in differential peaks

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Clinical Epigenetics

ISSN: 1868-7083

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