DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity

Table 1 Hypermethylated promoter regions in IM

Gene	Hypermethylated CpGs/promoter region	Total CpGs/promoter	logFC	p Value	FDR	Detected in
KDR	3	12	− 1.5	0.0000	0.0003	Ex vivo and in vivo
GCNT2	3	17	− 1.42	0.0000	0.0000	Ex vivo
CAPN13	3	6	− 1.39	0.0000	0.0000	Ex vivo
EYA4	7	51	− 1.37	0.0000	0.0013	Ex vivo and in vivo
ITGBL1	4	10	− 1.22	0.0001	0.0101	Ex vivo
SLC9A3	5	7	− 1.01	0.0001	0.0112	Ex vivo
CLIC6	5	11	− 0.89	0.0039	0.1244	Ex vivo
CHAD	7	8	− 0.69	0.0312	0.4136	Ex vivo
SORBS2	7	55	− 0.69	0.0003	0.0201	Ex vivo
TAS1R1	3	14	− 0.68	0.0293	0.4018	Ex vivo
PSCA	4	6	− 0.66	0.0266	0.3812	Ex vivo
CYP2E1	5	7	0.77	0.0063	0.1681	Ex vivo
TMEM176B	2	20	0.89	0.0022	0.0838	Ex vivo
GJB2	3	20	1.05	0.0000	0.0021	Ex vivo
CDX2	2	12	1.34	0.0000	0.0033	Ex vivo

Shown are the 15 genes with hypermethylated promoter regions in IM that also show altered gene expression. The in vivo samples represent antral samples with a high methylation cluster. logFC = log2 fold change; FDR = false discovery rate

ISSN: 1868-7083