Fig. 4

Differentiation- and stem cell-specific gene expression. A Selected up- and downregulated pit cell- and stem cell-specific genes between − W/R and + W/R conditions in antrum-, corpus- and fundus-derived cell cultures (FDR < 0.05). B Gene set enrichment of beta-catenin target genes (n = 66) [90] compared to differential gene expression between − W/R vs. + W/R. The moderated t-score of the DE results was used for ranking the genes. ES—enrichment score; NES—normalized enrichment score. C Normalized gene expression boxplots of TCF7L1 and the non-canonical Wnt signaling pathway genes WNT5A and ROR2. The boxplot displays the median, minimum and maximum normalized expression values of three biological replicates. D Table of DM CpGs within the genes displayed in C. n.s.—not significant