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Fig. 3 | Clinical Epigenetics

Fig. 3

From: DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity

Fig. 3

Differential gene expression in the stomach. A MDS of gene expression values in all samples. B Volcano plots of gene expression log2 fold changes between − W/R and + W/R (top) and between the stomach regions (+ W/R and − W/R combined per region) (bottom). The dashed horizontal and vertical lines indicate cutoffs of adjusted p value (FDR) < 0.2 and a log2 fold change at − 0.6 and 0.6, respectively. C Regional comparison of differentially regulated stem cell genes in undifferentiated samples (+ W/R, p < 0.05). D Heatmap of the top 15 up- and downregulated genes (FDR < 0.2) in all regional comparisons. The normalized expression is represented by row-wise standardization (z-score). Color code ranges from blue (low expression) to red (high expression). E Selected GO terms of biological process based on the GSEA of antrum versus fundus. NES—normalized enrichment score

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