Fig. 5

Effect of TET2 germline mutation on methylation and hydroxymethylation at transcription factor binding sites. A Volcano plots showing the effect of TET2 mutation status on average methylation at binding sites of different transcription factors overlapping PBMC enhancers at 0 months and B at 12 months. Average binding site methylation was defined using hypermethylated positions. Colored points had an FDR-corrected p value < 0.05. The most significant results are labeled with the transcription factor name. C Volcano plots showing the effect of TET2 mutation status on average hydroxymethylation at binding sites of different transcription factors at 0 months and D at 12 months