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Table 2 Major differentially methylated positions (DMPs, Δmeth > 5%)

From: Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity

DMP

Chr

BP

Gene

Feature

CGI

Δmeth

FDR

mQTLs (GRCh37)

cg10070864

15

57664490

 

IGR

Shelf

0.090

0.002

15:57665782

15:57667027

cg07199764

1

5347468

 

IGR

Opensea

 − 0.113

0.004

1:5343656

1:5346474

1:5346800

1:5347155

1:5347457

1:5348270

1:5348478

1:5350257

cg19192981

15

57664704

 

IGR

Shelf

0.085

0.004

15:57665782

15:57667027

cg07499182

13

33825496

STARD13

Body

Opensea

 − 0.064

0.005

13:33824770

13:33824988

13.33826125

13.33829245

13:33829571

cg25304129

22

26125490

 

IGR

Opensea

0.050

0.010

–

cg17015133

1

155111332

RAG1AP1

3'UTR

Shore

 − 0.052

0.011

1:155106697

cg14433904

8

78518428

 

IGR

Opensea

0.056

0.015

8:78519059

8.78519337

cg24833027

8

1897969

ARHGEF10

Body

Shelf

0.067

0.019

8:1902750

8:1899691

8:1902112

8:1897657

8:1900410

8:1900911

8:1900546

8.1901176

8.1899381

8:1895934

cg00401101

5

16509323

FAM134B

TSS1500

Opensea

0.060

0.021

5:16508674

5:16512364

5:16514269

cg08434374

11

44467306

 

IGR

Opensea

0.057

0.022

11:44469734

11:44471561

cg03453431

7

157225567

 

IGR

Opensea

 − 0.054

0.023

7:157226016

cg16958467

15

57655799

 

IGR

Opensea

0.108

0.024

15:57655776

15:57656919

cg00541777

2

3652840

COLEC11

TSS1500

Opensea

0.073

0.033

2:3650466

2:3652616

2:3654290

2:3654683

cg01156747

7

120659

 

IGR

Island

 − 0.142

0.035

7:120429

7:120174

7:124276

7:124586

7:116077

7:116054

7:116969

7:122450

7:121755

7:117441

cg17322118

1

85743732

BCL10

TSS200

Shore

0.053

0.035

1:85744472

1:85740024

1:85742860

1:85738953

cg12257246

8

25240570

DOCK5

Body

Opensea

 − 0.050

0.038

8:25240100

8:25245432

cg00267320

10

111533258

 

IGR

Opensea

0.058

0.040

10:111528480

10:111537595

cg00570954

12

94281309

 

IGR

Opensea

0.056

0.042

12:94281245

12:94285952

12:94282740

cg13883027

2

62892060

 

IGR

Opensea

0.145

0.043

2:62887884

2:62890171

2:62892323

cg25261547

19

49363369

PLEKHA4

Body

Opensea

 − 0.052

0.046

19:49364511

cg21728101

7

1979360

MAD1L1

Body

Shore

 − 0.052

0.048

7:1976457

7.1983928

cg14859874

1

154238265

UBAP2L

Body

Opensea

 − 0.122

0.049

1:154238063

1:154239283

1:154243115

1:154243245

  1. Δmeth delta methylation beta value; FDR false discovery rate; CHR chromosome; BP base position, CGI CpG island, mQTL methylation quantitative trait loci, IGR intergenic region, TSS200 transcription start site 200, TSS1500 transcription start site 1500, 3′UTR 3′ untranslated region
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Clinical Epigenetics

ISSN: 1868-7083

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