Table 1 Cohort summary statistics
Characteristics | Mild (n = 119) | Severe (n = 116) | All (n = 235) | Cohen’s d | |
|---|---|---|---|---|---|
Longitudinal ARMSS score | Median (IQR) | 1.21 (0.72, 1.86) | 8.63 (7.86, 9.20) | 2.86 (1.20, 8.62) | 8.87 |
Range | 0.17–3.01 | 6.52–9.92 | 0.17–9.92 | ||
Disease course at blood collection | RRMS | 118 (99.2%) | 46 (39.6%) | 163 (69.4%) | – |
SPMS | 0 (0.0%) | 70 (60.4%) | 71 (30.6%) | ||
Disease course at most recent visit | RRMS | 117 (98.3%) | 39 (33.6%) | 157 (66.8%) | Â |
SPMS | 1 (0.008%) | 77 (66.4%) | 78 (33.2%) | Â | |
Sex | Female | 119 (100.0%) | 116 (100.0%) | 235 (100.0%) | – |
Male | 0 (0%) | 0 (0%) | 0 (0%) | ||
Age at most recent visit | Median (IQR) | 53.57 (45.92, 62.14) | 53.47 (45.34, 61.33) | 52.41 (43.81, 59.31) | 0.15 |
Range | 29.00–76.35 | 28.80–76.35 | 28.80–76.21 | ||
Age at blood collection | Median (IQR) | 49.10 (40.75, 57.62) | 48.40 (40.10, 56.50) | 47.80 (39.85, 55.35) | 0.11 |
Range | 24.10–72.20 | 24.00–73.00 | 24.00–73.00 | ||
Symptom duration (years) | Median (IQR) | 15.90 (11.45, 20.98) | 24.18 (19.65, 31.70) | 19.92 (13.79, 26.49) | 0.95 |
Range | 5.85–38.11 | 11.91–47.13 | 5.85–47.13 | ||
ARR | Median (IQR) | 0.10 (0.00, 0.20) | 0.17 (0.00, 0.38) | 0.11 (0.00, 0.26) | 0.39 |
Range | 0.00–0.82 | 0.00–1.08 | 0.00–1.08 | ||
DMT at blood collection | Yes | 84 (70.5%) | 68 (58.6%) | 152 (64.7%) | – |
No | 35 (29.5%) | 48 (41.4%) | 83 (35.3%) | ||
Follow-up in MSBase (years) | Median (IQR) | 11.76 (10.24, 14.24) | 11.27 (9.78, 13.29) | 11.13 (9.49, 12.59) | 0.25 |
Range | 5.15–21.96 | 5.15–32.16 | 5.26–32.16 | ||
Number of EDSS scores assessed | Median (IQR) | 15.00 (11.00, 21.25) | 15.00 (11.00, 19.00) | 14.00 (10.00, 18.00) | 0.29 |
Range | 3.00–47.00 | 3.00–47.00 | 3.00–34.00 | ||