Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression

Clinical Epigenetics

Table 6 Methylation–transcriptome analysis in the cohort GSE56047

Probe	Coef.	β	95% CI β	Std. error β	T value	p value	Adj. p
MAD1L1___ILMN_2358069	cg02825527	0.0244	− 0.1708 to 0.2195	0.0995	0.2449	0.8066	0.834
MAD1L1___ILMN_2358074	cg02825527	− 0.0059	− 0.0609 to 0.0492	0.0281	− 0.2096	0.834	0.834
MAD1L1___ILMN_2358069	cg18302629	0.2439	0.058 to 0.4298	0.0947	2.5743	0.0102	0.0611
MAD1L1___ILMN_2358074	cg18302629	− 0.0156	− 0.0682 to 0.037	0.0268	− 0.5812	0.5613	0.834
MAD1L1___ILMN_2358069	cg19624444	− 0.1242	− 0.2527 to 0.0043	0.0655	− 1.8961	0.0582	0.1747
MAD1L1___ILMN_2358074	cg19624444	− 0.0135	− 0.0498 to 0.0228	0.0185	− 0.7316	0.4646	0.834

This table shows the results for association analysis between investigated CpG sites and MAD1L1 probes in the cohort GSE56047. In the models, the transcript level was a dependent numeric outcome variable, whereas CpG and other confounders (age, “racegendersite,” residual cell contamination, and chip ids) were predictors. Statistics for the model were calculated using a native implementation of the linear regression model in the R programming language. Confidence intervals for β coefficients were calculated using the R package “stats.” Raw p values were adjusted with the false discovery rate method

ISSN: 1868-7083