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Table 5 Odds ratio of LUAD or LUSC versus BPN according to continuous or tertiles of FUT7_CpG_1-7

From: Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma

Variables

LUAD versus BPN

 

LUSC versus BPN

Crude

Adjusted modela

Crude

Adjusted modelb

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

FUT7_CpG_1 (Per 1 SD decrease)

0.92 (0.77–1.09)

0.330

0.93 (0.77, 1.12)

0.448

 

1.56 (1.19–2.06)

0.001**

1.57 (1.14–2.17)

0.006**

Tertiles of FUT7_CpG_1

 T3 (≥ 0.280)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.270)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.200–0.270)

0.86 (0.56–1.31)

0.474

0.89 (0.56–1.40)

0.606

T2 (0.180–0.260)

1.89 (0.94–3.78)

0.074

2.58 (1.10–6.07)

0.029*

 T1 (< 0.200)

0.85 (0.56–1.29)

0.434

0.87 (0.55–1.36)

0.530

T1 (< 0.180)

2.67 (1.35–5.26)

0.005**

2.66 (1.16–6.09)

0.021*

P for trend

 

0.439

 

0.534

  

0.005**

 

0.026*

FUT7_CpG_2 (per 1 SD decrease)

1.05 (0.88–1.24)

0.601

1.03 (0.85–1.24)

0.776

 

1.69 (1.25–2.29)

 < 0.001***

1.72 (1.18–2.52)

0.005**

Tertiles of FUT7_CpG_2

 T3 (≥ 0.120)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.120)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.090–0.110)

0.86 (0.56–1.34)

0.502

0.84 (0.53–1.35)

0.474

T2 (0.090–0.110)

3.31 (1.47–7.49)

0.005**

3.13 (1.21–8.11)

0.019*

 T1 (< 0.090)

0.93 (0.61–1.40)

0.726

0.88 (0.56–1.37)

0.556

T1 (< 0.090)

3.92 (1.79–8.57)

 < 0.001***

2.97 (1.21–7.29)

0.017*

P for trend

 

0.745

 

0.570

  

 < 0.001***

 

0.027*

FUT7_CpG_3 (Per 1 SD decrease)

1.01 (0.85–1.20)

0.921

1.03 (0.86–1.24)

0.743

 

2.01 (1.41–2.87)

 < 0.001***

1.749 (1.166, 2.623)

0.007**

Tertiles of FUT7_CpG_3

 T3 (≥ 0.200)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.180)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.130–0.190)

0.88 (0.58–1.35)

0.566

0.84 (0.53–1.33)

0.449

T2 (0.120–0.170)

1.59 (0.76–3.36)

0.222

1.44 (0.60–3.45)

0.415

 T1 (< 0.130)

0.85 (0.55–1.29)

0.435

0.90 (0.57–1.41)

0.634

T1 (< 0.120)

3.68 (1.90–7.10)

 < 0.001***

2.90 (1.31–6.43)

0.009**

P for trend

 

0.433

 

0.629

  

 < 0.001***

 

0.008**

FUT7_CpG_4 (Per 1 SD decrease)

1.26 (1.05–1.50)

0.011*

1.24 (1.02–1.49)

0.029*

 

2.21 (1.64–2.98)

 < 0.001***

2.15 (1.49–3.09)

 < 0.001***

Tertiles of FUT7_CpG_4

 T3 (≥ 0.200)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.190)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.160–0.190)

0.93 (0.60–1.44)

0.738

0.83 (0.52–1.33)

0.444

T2 (0.160–0.180)

2.11 (0.96–4.64)

0.062

2.24 (0.89–5.62)

0.087

 T1 (< 0.160)

1.74 (1.14–2.65)

0.010*

1.62 (1.03–2.55)

0.037*

T1 (< 0.160)

5.32 (2.64–10.74)

 < 0.001***

5.19 (2.26–11.92)

 < 0.001***

P for trend

 

0.014*

 

0.049*

  

 < 0.001***

 

 < 0.001***

FUT7_CpG_5 (Per 1 SD decrease)

1.32 (1.08–1.60)

0.006**

1.31 (1.06–1.62)

0.014*

 

1.37 (1.02–1.84)

0.035*

1.173 (0.871, 1.579)

0.295

Tertiles of FUT7_CpG_5

 T3 (≥ 0.150)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.140)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.100–0.140)

1.20 (0.78–1.84)

0.407

1.19 (0.75–1.89)

0.453

T2 (0.090–0.130)

1.48 (0.74–2.98)

0.269

1.55 (0.67–3.57)

0.304

 T1 (< 0.100)

1.70 (1.09–2.64)

0.017*

1.74 (1.08, 2.81)

0.022*

T1 (< 0.090)

2.30 (1.16–4.56)

0.017*

1.70 (0.74–3.89)

0.209

P for trend

 

0.016*

 

0.019*

  

0.014*

 

0.229

FUT7_CpG_6 (Per 1 SD decrease)

1.17 (0.98–1.40)

0.076

1.14 (0.94–1.37)

0.187

 

1.34 (1.01–1.77)

0.046*

1.495 (1.045, 2.139)

0.028*

Tertiles of FUT7_CpG_6

 T3 (≥ 0.150)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.130)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.090–0.140)

0.66 (0.43–1.02)

0.062

0.63 (0.40–1.00)

0.050

T2 (0.090–0.120)

1.01 (0.51–1.99)

0.982

0.78 (0.34–1.81)

0.564

 T1 (< 0.090)

1.69 (1.07–2.66)

0.025*

1.51 (0.92–2.45)

0.101

T1 (< 0.090)

1.67 (0.89–3.12)

0.112

2.00 (0.90–4.44)

0.089

P for trend

 

0.005**

 

0.026*

  

0.113

 

0.092

FUT7_CpG_7 (Per 1 SD decrease)

1.05 (0.88–1.24)

0.602

1.05 (0.87–1.26)

0.618

 

2.12 (1.56–2.89)

 < 0.001***

2.147 (1.468, 3.140)

 < 0.001***

Tertiles of FUT7_CpG_7

 T3 (≥ 0.140)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.130)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.090–0.130)

0.98 (0.63–1.53)

0.935

0.99 (0.62–1.59)

0.981

T2 (0.080–0.120)

2.11 (0.99–4.51)

0.055

2.35 (0.97–5.72)

0.060

 T1 (< 0.090)

1.03 (0.68–1.56)

0.877

1.06 (0.68–1.65)

0.805

T1 (< 0.080)

5.19 (2.55–10.57)

 < 0.001***

4.52 (1.93–10.57)

 < 0.001***

P for trend

 

0.870

 

0.799

  

 < 0.001***

 

 < 0.001***

  1. Adjusted modela and Adjusted modelb were adjusted for age, sex, smoking, alcohol drinking, history of chronic lung diseases, personal tumor history
  2. *P < 0.05; **P < 0.01; ***P < 0.001