Variables | LC versus NC | Â | LC versus BPN | ||||||
---|---|---|---|---|---|---|---|---|---|
Crude | Adjusted modela | Crude | Adjusted modelb | ||||||
OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | ||
FUT7_CpG_1 (Per 1 SD decrease) | 1.62 (1.43–1.84) |  < 0.001*** | 1.65 (1.45–1.88) |  < 0.001*** |  | 1.04 (0.89–1.22) | 0.646 | 1.04 (0.87–1.23) | 0.699 |
Tertiles of FUT7_CpG_1 | |||||||||
 T3 (≥ 0.300) | 1.00 (reference) |  | 1.00 (reference) |  | T3 (≥ 0.280) | 1.00 (reference) |  | 1.00 (reference) |  |
 T2 (0.230–0.290) | 1.14 (0.83–1.57) | 0.405 | 1.21 (0.88–1.67) | 0.237 | T2 (0.190–0.270) | 1.02 (0.69–1.52) | 0.924 | 1.08 (0.70–1.66) | 0.719 |
 T1 (< 0.230) | 2.77 (2.07–3.71) |  < 0.001*** | 2.92 (2.17–3.96) |  < 0.001*** | T1 (< 0.190) | 1.12 (0.76–1.67) | 0.565 | 1.12 (0.73–1.73) | 0.608 |
P for trend |  |  < 0.001*** |  |  < 0.001*** |  |  | 0.556 |  | 0.611 |
FUT7_CpG_2 (Per 1 SD decrease) | 1.39 (1.23–1.57) |  < 0.001*** | 1.38 (1.21–1.57) |  < 0.001*** |  | 1.17 (0.99–1.37) | 0.055 | 1.15 (0.97–1.37) | 0.115 |
Tertiles of FUT7_CpG_2 | |||||||||
 T3 (≥ 0.130) | 1.00 (reference) |  | 1.00 (reference) |  | T3 (≥ 0.120) | 1.00 (reference) |  | 1.00 (reference) |  |
 T2 (0.100–0.120) | 1.12 (0.81–1.55) | 0.496 | 1.08 (0.77–1.50) | 0.668 | T2 (0.090–0.110) | 1.11 (0.73–1.67) | 0.630 | 1.10 (0.70–1.72) | 0.689 |
 T1 (< 0.100) | 1.83 (1.36–2.47) |  < 0.001*** | 1.76 (1.29–2.38) |  < 0.001*** | T1 (< 0.090) | 1.27 (0.86–1.86) | 0.233 | 1.22 (0.80–1.87) | 0.358 |
P for trend |  |  < 0.001*** |  |  < 0.001*** |  |  | 0.229 |  | 0.354 |
FUT7_CpG_3 (Per 1 SD decrease) | 1.56 (1.37–1.79) |  < 0.001*** | 1.59 (1.39–1.83) |  < 0.001*** |  | 1.14 (0.97, 1.33) | 0.115 | 1.130 (0.95, 1.35) | 0.172 |
Tertiles of FUT7_CpG_3 | |||||||||
 T3 (≥ 0.210) | 1.00 (reference) |  | 1.00 (reference) |  | T3 (≥ 0.190) | 1.00 (reference) |  | 1.00 (reference) |  |
 T2 (0.150–0.200) | 1.37 (1.01–1.86) | 0.045* | 1.34 (0.98–1.82) | 0.068 | T2 (0.120–0.180) | 0.99 (0.67–1.46) | 0.941 | 0.96 (0.62–1.47) | 0.836 |
 T1 (< 0.150) | 2.71 (2.02–3.62) |  < 0.001*** | 2.83 (2.09–3.82) |  < 0.001*** | T1 (< 0.120) | 1.24 (0.84–1.83) | 0.279 | 1.17 (0.76–1.79) | 0.477 |
P for trend |  |  < 0.001*** |  |  < 0.001*** |  |  | 0.286 |  | 0.489 |
FUT7_CpG_4 (Per 1 SD decrease) | 1.46 (1.29–1.64) |  < 0.001*** | 1.46 (1.29–1.66) |  < 0.001*** |  | 1.40 (1.19–1.66) |  < 0.001*** | 1.32 (1.10–1.58) | 0.003** |
Tertiles of FUT7_CpG_4 | |||||||||
 T3 (≥ 0.210) | 1.00 (reference) |  | 1.00 (reference) |  | T3 (≥ 0.200) | 1.00 (reference) |  | 1.00 (reference) |  |
 T2 (0.160–0.200) | 1.35 (0.98–1.86) | 0.066 | 1.32 (0.96–1.83) | 0.093 | T2 (0.150–0.190) | 1.19 (0.81–1.75) | 0.381 | 1.00 (0.66–1.53) | 0.991 |
 T1 (< 0.160) | 2.96 (2.16–4.05) |  < 0.001*** | 3.00 (2.17–4.16) |  < 0.001*** | T1 (< 0.150) | 2.51 (1.64–3.83) |  < 0.001*** | 2.15 (1.35–3.43) | 0.001** |
P for trend |  |  < 0.001*** |  |  < 0.001*** |  |  |  < 0.001*** |  | 0.002** |
FUT7_CpG_5 (Per 1 SD decrease) | 1.24 (1.09–1.41) | 0.001** | 1.23 (1.08–1.40) | 0.002** |  | 0.89 (0.75–1.06) | 0.184 | 0.90 (0.74–1.09) | 0.263 |
Tertiles of FUT7_CpG_5 | |||||||||
 T3 (≥ 0.150) | 1.00 (reference) |  | 1.00 (reference) |  | T3 (≥ 0.140) | 1.00 (reference) |  | 1.00 (reference) |  |
 T2 (0.110–0.140) | 0.85 (0.63–1.15) | 0.292 | 0.84 (0.62–1.15) | 0.274 | T2 (0.100–0.130) | 0.83 (0.55–1.24) | 0.364 | 0.81 (0.52–1.26) | 0.353 |
 T1 (< 0.110) | 1.82 (1.37–2.41) |  < 0.001*** | 1.81 (1.35–2.43) |  < 0.001*** | T1 (< 0.100) | 0.83 (0.56–1.22) | 0.331 | 0.79 (0.52–1.22) | 0.290 |
P for trend |  |  < 0.001*** |  |  < 0.001*** |  |  | 0.342 |  | 0.298 |
FUT7_CpG_6 (Per 1 SD decrease) | 1.18 (1.04–1.35) | 0.011* | 1.20 (1.05–1.37) | 0.007** |  | 0.94 (0.80–1.10) | 0.443 | 0.968 (0.809–1.158) | 0.719 |
Tertiles of FUT7_CpG_6 | |||||||||
 T3 (≥ 0.150) | 1.00 (reference) |  | 1.00 (reference) |  | T3 (≥ 0.140) | 1.00 (reference) |  | 1.00 (reference) |  |
 T2 (0.100–0.140) | 0.73 (0.54–0.98) | 0.037* | 0.72 (0.53–0.97) | 0.033* | T2 (0.090–0.130) | 0.46 (0.31–0.70) |  < 0.001*** | 0.52 (0.34–0.81) | 0.004** |
 T1 (< 0.100) | 1.45 (1.09–1.92) | 0.010* | 1.48 (1.11–1.97) | 0.008** | T1 (< 0.090) | 0.69 (0.46–1.04) | 0.076 | 0.74 (0.48–1.15) | 0.178 |
P for trend | Â | 0.011* | Â | 0.009** | Â | Â | 0.032* | Â | 0.097 |
FUT7_CpG_7 (Per 1 SD decrease) | 1.66 (1.46–1.89) |  < 0.001*** | 1.68 (1.47–1.92) |  < 0.001*** |  | 1.21 (1.03–1.42) | 0.018* | 1.18 (0.99–1.40) | 0.071 |
Tertiles of FUT7_CpG_7 | |||||||||
 T3 (≥ 0.150) | 1.00 (reference) |  | 1.00 (reference) |  | T3 (≥ 0.140) | 1.00 (reference) |  | 1.00 (reference) |  |
 T2 (0.100–0.140) | 0.96 (0.70–1.31) | 0.779 | 0.95 (0.69–1.31) | 0.757 | T2 (0.080–0.130) | 1.05 (0.71–1.55) | 0.818 | 0.99 (0.64–1.52) | 0.956 |
 T1 (< 0.100) | 2.93 (2.17–3.96) |  < 0.001*** | 3.04 (2.23–4.16) |  < 0.001*** | T1 (< 0.080) | 1.67 (1.11–2.51) | 0.014* | 1.50 (0.96–2.35) | 0.077 |
P for trend |  |  < 0.001*** |  |  < 0.001*** |  |  | 0.018* |  | 0.094 |