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Table 3 Odds ratio of LC versus NC or BPN according to continuous or tertiles of FUT7_CpG_1-7

From: Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma

Variables

LC versus NC

 

LC versus BPN

Crude

Adjusted modela

Crude

Adjusted modelb

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

FUT7_CpG_1 (Per 1 SD decrease)

1.62 (1.43–1.84)

 < 0.001***

1.65 (1.45–1.88)

 < 0.001***

 

1.04 (0.89–1.22)

0.646

1.04 (0.87–1.23)

0.699

Tertiles of FUT7_CpG_1

 T3 (≥ 0.300)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.280)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.230–0.290)

1.14 (0.83–1.57)

0.405

1.21 (0.88–1.67)

0.237

T2 (0.190–0.270)

1.02 (0.69–1.52)

0.924

1.08 (0.70–1.66)

0.719

 T1 (< 0.230)

2.77 (2.07–3.71)

 < 0.001***

2.92 (2.17–3.96)

 < 0.001***

T1 (< 0.190)

1.12 (0.76–1.67)

0.565

1.12 (0.73–1.73)

0.608

P for trend

 

 < 0.001***

 

 < 0.001***

  

0.556

 

0.611

FUT7_CpG_2 (Per 1 SD decrease)

1.39 (1.23–1.57)

 < 0.001***

1.38 (1.21–1.57)

 < 0.001***

 

1.17 (0.99–1.37)

0.055

1.15 (0.97–1.37)

0.115

Tertiles of FUT7_CpG_2

 T3 (≥ 0.130)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.120)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.100–0.120)

1.12 (0.81–1.55)

0.496

1.08 (0.77–1.50)

0.668

T2 (0.090–0.110)

1.11 (0.73–1.67)

0.630

1.10 (0.70–1.72)

0.689

 T1 (< 0.100)

1.83 (1.36–2.47)

 < 0.001***

1.76 (1.29–2.38)

 < 0.001***

T1 (< 0.090)

1.27 (0.86–1.86)

0.233

1.22 (0.80–1.87)

0.358

P for trend

 

 < 0.001***

 

 < 0.001***

  

0.229

 

0.354

FUT7_CpG_3 (Per 1 SD decrease)

1.56 (1.37–1.79)

 < 0.001***

1.59 (1.39–1.83)

 < 0.001***

 

1.14 (0.97, 1.33)

0.115

1.130 (0.95, 1.35)

0.172

Tertiles of FUT7_CpG_3

 T3 (≥ 0.210)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.190)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.150–0.200)

1.37 (1.01–1.86)

0.045*

1.34 (0.98–1.82)

0.068

T2 (0.120–0.180)

0.99 (0.67–1.46)

0.941

0.96 (0.62–1.47)

0.836

 T1 (< 0.150)

2.71 (2.02–3.62)

 < 0.001***

2.83 (2.09–3.82)

 < 0.001***

T1 (< 0.120)

1.24 (0.84–1.83)

0.279

1.17 (0.76–1.79)

0.477

P for trend

 

 < 0.001***

 

 < 0.001***

  

0.286

 

0.489

FUT7_CpG_4 (Per 1 SD decrease)

1.46 (1.29–1.64)

 < 0.001***

1.46 (1.29–1.66)

 < 0.001***

 

1.40 (1.19–1.66)

 < 0.001***

1.32 (1.10–1.58)

0.003**

Tertiles of FUT7_CpG_4

 T3 (≥ 0.210)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.200)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.160–0.200)

1.35 (0.98–1.86)

0.066

1.32 (0.96–1.83)

0.093

T2 (0.150–0.190)

1.19 (0.81–1.75)

0.381

1.00 (0.66–1.53)

0.991

 T1 (< 0.160)

2.96 (2.16–4.05)

 < 0.001***

3.00 (2.17–4.16)

 < 0.001***

T1 (< 0.150)

2.51 (1.64–3.83)

 < 0.001***

2.15 (1.35–3.43)

0.001**

P for trend

 

 < 0.001***

 

 < 0.001***

  

 < 0.001***

 

0.002**

FUT7_CpG_5 (Per 1 SD decrease)

1.24 (1.09–1.41)

0.001**

1.23 (1.08–1.40)

0.002**

 

0.89 (0.75–1.06)

0.184

0.90 (0.74–1.09)

0.263

Tertiles of FUT7_CpG_5

 T3 (≥ 0.150)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.140)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.110–0.140)

0.85 (0.63–1.15)

0.292

0.84 (0.62–1.15)

0.274

T2 (0.100–0.130)

0.83 (0.55–1.24)

0.364

0.81 (0.52–1.26)

0.353

 T1 (< 0.110)

1.82 (1.37–2.41)

 < 0.001***

1.81 (1.35–2.43)

 < 0.001***

T1 (< 0.100)

0.83 (0.56–1.22)

0.331

0.79 (0.52–1.22)

0.290

P for trend

 

 < 0.001***

 

 < 0.001***

  

0.342

 

0.298

FUT7_CpG_6 (Per 1 SD decrease)

1.18 (1.04–1.35)

0.011*

1.20 (1.05–1.37)

0.007**

 

0.94 (0.80–1.10)

0.443

0.968 (0.809–1.158)

0.719

Tertiles of FUT7_CpG_6

 T3 (≥ 0.150)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.140)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.100–0.140)

0.73 (0.54–0.98)

0.037*

0.72 (0.53–0.97)

0.033*

T2 (0.090–0.130)

0.46 (0.31–0.70)

 < 0.001***

0.52 (0.34–0.81)

0.004**

 T1 (< 0.100)

1.45 (1.09–1.92)

0.010*

1.48 (1.11–1.97)

0.008**

T1 (< 0.090)

0.69 (0.46–1.04)

0.076

0.74 (0.48–1.15)

0.178

P for trend

 

0.011*

 

0.009**

  

0.032*

 

0.097

FUT7_CpG_7 (Per 1 SD decrease)

1.66 (1.46–1.89)

 < 0.001***

1.68 (1.47–1.92)

 < 0.001***

 

1.21 (1.03–1.42)

0.018*

1.18 (0.99–1.40)

0.071

Tertiles of FUT7_CpG_7

 T3 (≥ 0.150)

1.00 (reference)

 

1.00 (reference)

 

T3 (≥ 0.140)

1.00 (reference)

 

1.00 (reference)

 

 T2 (0.100–0.140)

0.96 (0.70–1.31)

0.779

0.95 (0.69–1.31)

0.757

T2 (0.080–0.130)

1.05 (0.71–1.55)

0.818

0.99 (0.64–1.52)

0.956

 T1 (< 0.100)

2.93 (2.17–3.96)

 < 0.001***

3.04 (2.23–4.16)

 < 0.001***

T1 (< 0.080)

1.67 (1.11–2.51)

0.014*

1.50 (0.96–2.35)

0.077

P for trend

 

 < 0.001***

 

 < 0.001***

  

0.018*

 

0.094

  1. Adjusted modela was adjusted for age, sex
  2. Adjusted modelb was adjusted for age, sex, smoking, alcohol drinking, history of chronic lung diseases, personal tumor history
  3. *P < 0.05; **P < 0.01; ***P < 0.001