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Fig. 5 | Clinical Epigenetics

Fig. 5

From: LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer

Fig. 5

Integrative analysis of gene expression and DNA methylation in HPV16-negative OPSCC patients. a Leftside: heatmap summarizing expression data for the up-regulated genes in HPV16-negative OPSCC patients (P) who relapsed within 2 years from the end of treatment (P4, P9) with those who did not (P19, P36, P74). Data are shown as normalized expression values in log2 and centered on the median value. Rightside: heatmap showing the methylation values (beta value) in relapsed (P4, P9, P10, P32, P43) vs relapsed-free (P19, P30, P36, P72, P74) HPV16-negative OPSCC patients. b Kaplan–Meier estimates overall survival according to high- and low-methylation levels of the PIK3C2G cg17881542 in MethSurv

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