Fig. 1From: Gene body methylation in cancer: molecular mechanisms and clinical applicationsEffect of transcription on gene body methylation in RHPDF1 gene. A In embryoid body (EB) cells, RNA pol II recruits SETD2, methylating trimethylation of H3K36, in turn recruits DNMT3B leading to gene body methylation. B In ES cells, CGIs are bounding by CFP1, which mediates trimethylation of H3K4, blocking the recruitment of DNMTsBack to article page