An explorative epigenome-wide association study of plasma renin and aldosterone concentration in a Ghanaian population: the RODAM study

Table 3 Association between z-transformed DNA methylation levels of top differentially methylated positions (independent variable) and renin, aldosterone, and aldosterone-to-renin-ratio concentration (dependent variable)

	chr	pos	Gene symbol	Gene group	Regression coeff	Explained variance (%)
Renin
cg02105843	chr11	522,809	Intergenic		− 9.08	15.24
Aldosterone
cg06215643	chr22	50,119,046			44.16	18.45
cg03123773	chr12	56,510,201	RPL41	TSS200	− 59.72	20.43
cg21178689	chr9	138,594,307	KCNT1	Body	45.22	17.54
cg17876128	chr1	4,068,541	Intergenic		− 53.90	19.69
cg14771658	chr2	167,350,883	Intergenic		50.93	20.03
cg18784903	chr7	1,337,353	Intergenic		45.30	20.12
cg09869144	chr16	83,948,818	MLYCD	Body	73.58	23.4
cg15627834	chr3	170,078,469	SKIL	Body	− 56.33	23.15
cg06124066	chr7	157,885,905	PTPRN2	Body	− 63.38	17.62
cg24500222	chr7	71,747,028	CALN1	5'UTR	− 60.77	16.42
ARR
cg15602420	chr1	20,205,059	intergenic		− 13.25	19.49

Model: trait (untransformed) ~ DNAm(Mval) + sex + age + BMI + diabetes + hypertension + CD8T + CD4T + NK + Bcell + Mono + Gran + batch + position; ARR, aldosterone-to-renin-ratio

ISSN: 1868-7083