An explorative epigenome-wide association study of plasma renin and aldosterone concentration in a Ghanaian population: the RODAM study

Table 2 Epigenome-wide significant differentially methylated positions associated with renin, aldosterone and aldosterone/renin ratio

	Regres.Coeff*	p-value	FDR adj. p-val	chr	pos	Gene symbol**	Gene group	Methylation, % (sd)***
Renin
cg02105843	− 0.149	1.65E-08	0.0071	chr11	522,809	intergenic	90.46 (2.06)
Aldosterone
cg06215643	0.209	2.73E-08	0.0084	chr22	50,119,046	intergenic	57.05 (5.13)
cg03123773	− 0.613	3.90E-08	0.0084	chr12	56,510,201	RPL41	TSS200	5.83 (3.24)
cg21178689	0.291	1.08E-07	0.0154	chr9	138,594,307	KCNT1	Body	64.4 (7.16)
cg17876128	− 0.247	1.46E-07	0.0156	chr1	4,068,541	intergenic	86.45 (4.01)
cg14771658	0.196	2.16E-07	0.0185	chr2	167,350,883	intergenic	37.57 (5.31)
cg18784903	0.270	2.90E-07	0.0185	chr7	1,337,353	intergenic	65.02 (6.38)
cg09869144	0.150	3.01E-07	0.0185	chr16	83,948,818	MLYCD	Body	98.18 (0.36)
cg15627834	− 0.489	4.55E-07	0.0245	chr3	170,078,469	SKIL	Body	91.89 (9.01)
cg06124066	− 0.148	8.83E-07	0.0421	chr7	157,885,905	PTPRN2	Body	91.01 (1.78)
cg24500222	− 0.173	1.10E-06	0.0472	chr7	71,747,028	CALN1	5'UTR	76.47 (4.74)
ARR
cg15602420	− 0.217	1.12E-07	0.0481	chr1	20,205,059	Intergenic	77.9 (5.53)

^*For M-values, model adjusted for covariates: sex, age, BMI, diabetes, hypertension, CD8T, CD4T, NK, Bcell, Monocytes, Granulocytes, batch, position; ARR, aldosterone-to-renin-ratio
^**Annotated using UCSC genome browser, genome build hg37
^***Methylation level calculated as: methylation beta*100

ISSN: 1868-7083