Fig. 2

Analyses of global methylation changes between study timepoints. A PCA plot indicating that genome-wide methylation of blood profiles of participants before intervention (blue colour) are different and more heterogeneous than profiles from the second timepoint (green colour), third timepoint (orange colour) and healthy controls (red colour). B Comparison of median global methylation levels indicates an increase in methylation between the first and both the second and the third timepoints of the study with global methylation levels at the second and third timepoint resembling the methylation level of healthy blood (red colour)