Dynamic patterns of blood lipids and DNA methylation in response to statin therapy

Clinical Epigenetics

Table 4 Piecewise linear–linear growth curve models of latent intercept and slopes of longitudinal trends of DNA methylation on candidate CpGs

Trait	Regressors	Intercept			Pre_slope			Post_slope			Model fit indices
		Estimate	95% CI	P value	Estimate	95% CI	P value	Estimate	95% CI	P value
cg10177197	Age	− 0.003	− 0.007, 0.001	0.214	− 0.001	− 0.003, 0.001	0.197	− 0.005	− 0.013, 0.003	0.258	Chi-square value: 45.9 (DF: 32, P = 0.053), CFI: 0.897, RMSEA: 0.029
	Sex	0.066	− 0.005, 0.138	0.070	0.042	0.012, 0.073	0.006	− 0.062	− 0.184, 0.059	0.316
	Statin	0.053	− 0.030, 0.136	0.213	0.011	− 0.025, 0.048	0.539	–	–	–
cg17901584	Age	0.008	0.000, 0.017	0.061	0.000	− 0.004, 0.003	0.807	− 0.005	− 0.021, 0.011	0.554	Chi-square value: 34.5 (DF: 32, P = 0.349), CFI: 0.957, RMSEA: 0.012
	Sex	− 0.230	− 0.393, − 0.067	0.006	− 0.080	− 0.142, − 0.017	0.012	0.251	0.003, 0.499	0.047
	Statin	− 0.244	− 0.480, − 0.008	0.042	− 0.079	− 0.193, 0.036	0.177	–	–	–
cg27243685	Age	− 0.005	− 0.009, − 0.001	0.009	0.000	− 0.003, 0.002	0.719	− 0.005	− 0.020, 0.011	0.561	Chi-square value: 38.1 (DF: 22, P = 0.018), CFI: 0.791, RMSEA: 0.037
	Sex	− 0.120	− 0.194, − 0.047	0.001	− 0.030	− 0.074, 0.015	0.190	− 0.007	− 0.151, 0.136	0.921
	Statin	0.153	0.073, 0.232	< 0.001	0.079	0.031, 0.127	0.001	–	–	–

Pre_slope means the slope in the phase from the first observation of not using statin until the observation of starting to use statin (for statin users) or the slope from the first observation to the last observation of repeated measurements (nonstatin users); Post_slope means the slope in the phase from the observation of starting to use statin until the last observation of repeated measurements (only for statin users). The Bonferroni adjusted significance level was set to 0.017 (0.05/3). CI: confidence interval; DF: degree of freedom; CFI: comparative fit index; RMSEA: root-mean-square error of approximation

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