Dynamic patterns of blood lipids and DNA methylation in response to statin therapy

Clinical Epigenetics

Table 3 Piecewise linear–linear growth curve models of latent intercept and slopes of longitudinal trends of blood lipid levels

Trait	Regressors	Intercept			Pre_slope			Post_slope			Model fit indices
		Estimate	95% CI	P value	Estimate	95% CI	P value	Estimate	95% CI	P value
TC	Age	− 0.002	− 0.014, 0.010	0.741	− 0.007	− 0.011, − 0.004	< 0.001	− 0.023	− 0.049, 0.003	0.081	Chi-square value: 167.0 (DF: 43, P < 0.001), CFI: 0.812, RMSEA: 0.074
	Sex	0.522	0.316, 0.728	< 0.001	0.031	− 0.032, 0.094	0.342	0.217	− 0.183, 0.617	0.289
	Statin	− 0.816	− 1.032, − 0.601	< 0.001	− 0.483	− 0.594, − 0.372	< 0.001	–	–	–
LDL	Age	− 0.003	− 0.015, 0.009	0.589	− 0.005	− 0.008, − 0.001	0.007	− 0.020	− 0.045, 0.005	0.110	Chi-square value: 170.2 (DF: 55, < 0.001), CFI: 0.798, RMSEA: 0.063
	Sex	0.206	0.003, 0.409	0.047	0.025	− 0.036, 0.086	0.414	0.178	− 0.162, 0.518	0.305
	Statin	− 0.840	− 1.048, − 0.632	< 0.001	− 0.483	− 0.598, − 0.367	< 0.001	–	–	–
TG	Age	0.006	− 0.002, 0.014	0.114	0.001	− 0.002, 0.003	0.671	− 0.003	− 0.014, 0.007	0.550	Chi-square value: 97.2 (DF: 55, < 0.001), CFI: 0.914, RMSEA: 0.039
	Sex	− 0.077	− 0.253, 0.100	0.396	− 0.005	− 0.056, 0.045	0.832	0.107	− 0.032, 0.246	0.132
	Statin	0.050	− 0.172, 0.272	0.658	− 0.050	− 0.117, 0.018	0.149	–	–	–

Pre_slope means the slope before starting to use statins (for statin users) or the slope from the first observation to the last observation (nonstatin users); Post_slope means the slope after starting to use statins until the last observation (only for statin users). The Bonferroni adjusted significance level was set to 0.013 (0.05/4). TC: total cholesterol, LDL: low-density lipoprotein cholesterol; TG: total triglyceride; CI: confidence interval; DF: degree of freedom; CFI: comparative fit index; RMSEA: root-mean-square error of approximation

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