Dynamic patterns of blood lipids and DNA methylation in response to statin therapy

Clinical Epigenetics

Table 2 Associations between blood lipids and DNA methylation from the mixed effect models

Dependent variables	Independent variables	Estimate	95% CI	P value
cg10177197	TC	− 0.001	− 0.003, 0.001	0.263
	LDL	− 0.003	− 0.005, 0.000	0.023
	HDL	− 0.007	− 0.014, 0.000	0.051
	TG	0.004	0.001, 0.006	0.015
cg17901584	TC	0.016	0.011, 0.020	4.70E−12
	LDL	0.014	0.009, 0.020	3.35E−07
	HDL	0.038	0.023, 0.054	2.46E−06
	TG	− 0.002	− 0.008, 0.005	0.631
cg27243685	TC	− 0.005	− 0.008, − 0.003	1.28E−06
	LDL	− 0.004	− 0.007, − 0.002	6.93E−04
	HDL	− 0.013	− 0.020, − 0.006	1.84E−04
	TG	0.003	0.000, 0.006	0.031

Age, sex and smoking were adjusted for as covariates. The Bonferroni adjusted significance level was set to 0.013 (0.05/4). TC: total cholesterol, LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol; TG: total triglyceride; CI: confidence interval

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