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Fig. 6 | Clinical Epigenetics

Fig. 6

From: SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia

Fig. 6

Biological role of SLC22A3 on leukemic cell lines and AML fresh BMMNCs. A Transcript level of SLC22A3 in HL60, K562 and 2 AML fresh BMMNCs (patient1 and patient4) after transfected with small interfering (si)RNA against SLC22A3 and negative control. BE The effect of SLC22A3 under-expression on cell proliferation. SLC22A3 under-expression significantly increased cell proliferation ability in HL60, K562, and fresh BMMNCs from Patient1 and Patient4. F, G The effect of SLC22A3 under-expression on cell apoptosis. SLC22A3 under-expression significantly decreased cell apoptosis ratio in HL60 and K562 cells

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