Fig. 4
From: SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia
Regulation effect of DNA methylation on SLC22A3 expression. A SLC22A3 expression level detected by RT-qPCR in controls, MDS and AML patients. B Correlation between SLC22A3 methylation (RQ-MSP) and expression (RT-qPCR). C, D SLC22A3 methylation and expression pattern in six leukemic cell lines. E, F SLC22A3 expression on HL60 and K562 changed with the concentration of DAC treatment (0, 0.1, 1, 10 μmol/L). G–J SLC22A3 expression changed with the concentration of DAC treatment on AML fresh CMMNCs isolated from four newly diagnosed AML patients (Patient1-M2a, Patient2-M2b, Patient3-M4a, and Patient4-M5b). *: P < 0.05