Fig. 4
From: Investigating pathological epigenetic aberrations by epi-proteomics
MALDI imaging workflow. Tissue sections are mounted on slides appropriate for MALDI imaging, are digested with trypsin (as an optional step) and covered with a MALDI matrix. The tissue slides are scanned by a laser beam, which generates MS spectra for each xy coordinate. MALDI imaging profiles can guide the selection of area of interest to be laser microdissected and analyzed by LC/MS