Fig. 1
From: Investigating pathological epigenetic aberrations by epi-proteomics
Role of histones in the regulation of gene expression. Histone posttranslational modifications (PTMs) and variants contribute to the regulation of the expression of genes, determining changes at the levels of transcripts, proteins and metabolites that can lead to aberrant phenotypes. In turn, proteins and metabolites can influence the levels and the effects of histone PTMs and variants, by affecting the levels of histone-modifying enzymes (HMEs), histone chaperones and readers, and intermediate metabolites