Skip to main content
Fig. 1 | Clinical Epigenetics

Fig. 1

From: Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer

Fig. 1

Correlation between PRELP gene expression and genetic mutation, copy number alteration (CNA), and DNA methylation in bladder cancer. A Pie chart showing the percentage of missense mutations in the PRELP gene (n = 408). Wild type is shown in gray and missense mutations are shown in black. B PRELP mRNA expression (z-scores relative to diploid samples; y-axis) are plotted against a missense mutation (n = 1) or wild type (n = 407; x-axis). C Pie chart showing CNAs in PRELP gene (n = 404). Shallow deletion (CNA = − 1), diploid (CNA = 0), gain (CNA =  + 1) and amplification (CNA =  + 2) are shown in white, light gray, gray, and black, respectively. D Same as B, but plotted by distinct type of CNAs (x-axis); deep deletion (n = 0), shallow deletion (n = 62), diploid (n = 218), gain (n = 122), and amplification (n = 2). E Same as B, but plotted against DNA methylation level (beta-values; x-axis) of PRELP (n = 408). Spearman correlation coefficient (r) between DNA methylation and PRELP mRNA expression is shown

Back to article page