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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer

Fig. 5

The LIFR-AS1 promoter region is hypermethylated in CRC. A MethPrimer predicted potential CpG islands (blue region) and depicted CpG sites (red vertical line and bar chart) within the LIFR-AS1 promoter region. B Bisulfite sequencing PCR (BSP) showed that a CpG site at position 16 was methylated in tumors. C BSP was used to detect the methylation status of LIFR-AS1 in tumors and paired adjacent normal tissues. D Results of BSP detection of the methylation status of the LIFR-AS1 promoter region using 18 colorectal cancers and paired adjacent normal tissues. E Receiver operating characteristic curve showing the profiles of sensitivity and specificity of the methylation status to distinguish colorectal cancers from normal tissues. F LIFR-AS1 and LIFR mRNA expression levels were significantly lower in hypermethylated groups compared to hypomethylated groups

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