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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer

Fig. 4

The features of LIFR-AS1 and neighboring genes in CRC. A The position of LIFR-AS1 and neighboring genes (LIFR and miR-3650) annotated in GRCh38. B The expression of LIFR in 41 matched normal and tumor CRC samples from TCGA. C Correlation analysis between LIFR-AS1 and LIFR expression in GSE156451 and TCGA datasets. D Correlations between LIFR expression and methylation level of CpG loci located in LIFR-AS1 promoter region. E Expression levels of LIFR in LIFR-AS1 overexpression cells using qRT-PCR analysis. F The expression of LIFR in t-SNE plots colored by cell cluster. G The expression of miR-3650 in CRC samples from TCGA. H The transcriptional regulatory network showing the target genes of LIFR-AS1. Color represents the P value. I Luciferase activities of LIFR-AS1_WT and LIFR-AS1_MUT with or without transfection of hsa-miR-29b-3p

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