Fig. 1

Conjoint analysis of the methylome and transcriptome of lncRNAs in CRC. A Volcano plot of differentially expressed lncRNAs between tumors and normal tissues. B Venn diagram displaying the overlap of lncRNAs identified using three algorithms (edgeR, limma and DESeq2). C Manhattan plot of CpG sites in the promoter regions of lncRNA genes; dots above the blue line indicate CpG sites with P value < 0.05. D Heatmap of top five up- and downregulated lncRNAs between tumors and normal tissues and the hierarchical clustering heat map of 10 lncRNA-related CpG sites. Color scale represents the relative expression level or methylation level for each lncRNA